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Clinical Evidence
RESPIRATORY
WOMEN’S HEALTH
PAEDIATRIC HEALTH
GASTROINTESTINAL HEALTH
ORTHO & PAIN DISORDERS
LIFESTYLE DISORDERS
DERMATOLOGY
RESPIRATORY
BLM Helix
Assessment report on Hedera helix.
A randomized, controlled, double-blind, multi-
center
trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575 ®) vs. placebo in the treatment of adults with acute cough.
Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs
an other
ivy leaves extract.
Treatment of chronic bronchitis with ivy leaf special extract-
multicenter
post-marketing surveillance study in 1,350 patients.
Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre post
marketing study in 9657 patients.
Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections.
Assessment of the efficacy and safety of ivy leaf (
Hedera
helix) cough syrup compared with acetylcysteine in adults and children with acute bronchitis.
BLM Respira
Assessment report on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix
Efficacy and tolerability of EPs 7630 in patients (aged 6–18 years old) with acute bronchitis
Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial
Treatment with EPs 7630, a Pelargonium Sidoides Root Extract, Is Effective and Safe in Patients with the Common Cold: Results From a Randomized, Double Blind, Placebo Controlled Clinical Trial
Unlocking the therapeutic potential of Pelargonium sidoides natural extract: A scoping review
Assessment report on Thymus vulgaris L., vulgaris zygis L., herba
Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled multicentre clinical trial
Thymus vulgaris ameliorates cough in children with asthma exacerbation: a randomized, triple-blind, placebo-controlled clinical trial
WOMEN’S HEALTH
BLM FemStarte
Effect of a yoghurt drink containing
Lactobacillus
strains on bacterial vaginosis in women – a double-blind, randomised, controlled clinical pilot
trial.
Ability of an orally administered lactobacilli preparation to improve the quality of the neovaginal microflora in male to female transsexual women.
Influence of orally administered probiotic l
actobacillus
strains on vaginal microbiota in women with breast cancer during chemotherapy: A randomized placebo-controlled double-blinded pilot study.
Vaginal Lactobacillus microbiota of healthy women in the late first trimester of pregnancy.
Strategies for the evaluation and selection of potential vaginal probiotics from human sources: an exemplary
study.
BLM Prenatalis
5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology
Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health
Vitamin B-12 Supplementation during Pregnancy and Early Lactation Increases Maternal, Breast Milk, and Infant Measures of Vitamin B-12 Status
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia
A Comparative Study Between Ferric Pyrophosphate And Ferrous Ascorbate In Pregnant Women With Anemia In A Tertiary Care Centre
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy
The Effects of Iodine Deficiency in Pregnancy and Infancy
Iodine Status, Thyroid Disorder and Feto-Maternal Outcome among the Tribal Pregnant Women of Eastern Himalayas
BLM OvaVital
Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome
Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action
Long-term treatment with α-lipoic acid and myo inositol positively affects clinical and metabolic features of polycystic ovary syndrome
Green Tea Supplement in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
The Impact of Green Tea Supplementation on Anthropometric Indices and Inflammatory Cytokines in Women with Polycystic Ovary Syndrome
Vitamin D, PCOS and androgens in men: a systematic review
Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial
BLM MenoCare
Evaluation of the Efficacy and Safety of Rheum rhaponticum Root Extract (ERr 731) for Menopausal Symptoms in Perimenopausal Indian Women: An Interim Analysis
Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial
The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women
The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women
The effect of salvia officinalis tablet on hot flashes, night sweating, and estradiol hormone in postmenopausal women
The Impact of Salvia officinalis Extract on Depression in Postmenopausal Women: A Randomized Clinical Trial
Dose response to vitamin D supplementation in postmenopausal women: a randomized trial
PAEDIATRIC HEALTH
BLM LrGG
Effect of Lactobacillus rhamnosus GG in persistent diarrhea in Indian children: a randomized controlled trial.
Effect of Lactobacillus rhamnosus GG in Persistent Diarrhea in Indian Children.
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children.
Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children.
Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study.
Randomised controlled trial of Lactobacillus rhamnosus (LGG) versus placebo in children presenting to the emergency department with acute gastroenteritis: the PECARN probiotic study protocol.
BLM ColiBiome
Probiotic treatment with ab-kolicare® causes changes in the microbiota which correlate with a reduction in crying time.
Infantile colic treated with bifidobacterium longum CECT7894 and pediococcus pentosaceus CECT8330: a randomized, double-blind, placebo-controlled trial.
Pediococcus pentosaceus CECT 8330 and bifidobacterium longum CECT 7894 show a trend towards lowering infantile excessive crying syndrome in a pilot clinical trial.
Gut microbiota dysbiosis and role of probiotics in infant colic.
BLM NeuroKids
Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders
l-Carnosine As an Adjunctive Therapy to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Effects of l-Carnosine Supplementation on Sleep Disorders and Disease Severity in Autistic Children: A Randomized, Controlled Clinical Trial
The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension
Impact of Vitamin D Supplementation on Attention-Deficit Hyperactivity Disorder in Children
GASTROINTESTINAL HEALTH
BLM LrGG
Efficacy of Lactobacillus rhamnosus GG in acute watery diarrhoea of Indian children: a randomised controlled trial.
Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults.
Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis.
BLM PreBiome
Effects of a Food Supplement with a Wild Thyme (Thymus serpyllum L.) Extract on Gut Health and the Microbiome in Humans: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Intervention Study Focused on the Intestinal Microbiome to Evaluate the Impact of a Wild Thyme Extract (Thymus Serpyllum) Extract With Anti-inflammatory and Metabolic Properties Against Functional Gastrointestinal Disorders. ONGOING
The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice
Review of Ethnobotanical, Phytochemical, and Pharmacological Study of Thymus serpyllum L.
Influence of lyophilized Thymus serpyllum L. extracts on the gastrointestinal system: Spasmolytic, antimicrobial and antioxidant properties
BLM EasyGo
A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Weizmannia coagulans BC99 in the treatment of chronic constipation in adults
Weizmannia coagulans BC99 Relieves Constipation Symptoms by Regulating Inflammatory, Neurotransmitter, and Lipid Metabolic Pathways: A Randomized, Double-Blind, Placebo-Controlled Trial
Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial
Weizmannia Coagulans BC99 Prevents Loperamide-Induced Functional Constipation in Mice Through Increased Intestinal Peristalsis and Modulation of Gut Microbiota Dysbiosis
Comprehensive genomic analysis and evaluation of in vivo and in vitro safety of Heyndrickxia coagulans BC99
ORTHO & PAIN DISORDERS
BLM OsteoVida
Avocado/soy unsaponifiables can redress the balance between serum antioxidant and oxidant levels in patients with osteoarthritis: a double-blind, randomized, placebo-controlled, cross-over study.
Joint dysfunctionality alleviation along with systemic inflammation reduction following arthrocen treatment in patients with knee osteoarthritis: a randomized double-blind placebo-controlled clinical trial.
Efficacy and safety of avocado-soybean unsaponifiables for the treatment of hip and knee osteoarthritis: A systematic review and meta-analysis of randomized placebo-controlled trials.
Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials.
Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect.
BLM Vitalis
The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review
Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial
Rationale for a Vitamin K2 and Vitamin D3 Intervention Trial in Children and Adolescents with Low-Energy Bone Fractures
Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis
Effects of vitamin k2 and d3 supplementation on cardiac and systemic inflammation: a randomized controlled trial
BLM MyoActiv
The Effect of β-Hydroxy-β-Methylbutyrate (HMB) on Sarcopenia and Functional Frailty in Older Persons: A Systematic Review
Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Older Adults with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Study
Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial
Lactobacillus plantarum TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial
Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans
Vitamin D Deficiency and Sarcopenia in Older Persons
Serum vitamin D status inversely associates with a prevalence of severe sarcopenia among female patients with rheumatoid arthritis
LIFESTYLE DISORDERS
BLM CholesLife
Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels.
Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults.
A combination of Lactoplantibacillus plantarum strains CECT7527, CECT7528, and CECT7529 plus monacolin K reduces blood cholesterol: results from a randomized, double-blind, placebo-controlled study.
The Impacts of Lactiplantibacillus plantarum on the Functional Properties of Fermented Foods: A Review of Current Knowledge.
Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials.
BLM GlucoBalance
Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes
Efficacy of Berberis aristata Compared to Metformin in Improving Glycemic Control and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
Clove bud (Syzygium aromaticum L.) polyphenol helps to mitigate metabolic syndrome by establishing intracellular redox homeostasis and glucose metabolism: A randomized, double-blinded, active-controlled comparative study
Water-soluble polyphenol-rich clove extract lowers pre- and post-prandial blood glucose levels in healthy and prediabetic volunteers: an open label pilot study
Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study
BLM VenoFera
EMA Assessment report on Vitis vinifera L., folium – Final
Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review
Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency–results of a double-blind placebo-controlled study
Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial
Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial
Improvement of Cutaneous Microcirculation and Oxygen Supply in Patients with Chronic Venous Insufficiency by Orally Administered Extract of Red Vine Leaves AS 195
Efficacy of the red vine leaf extract AS 195 in Chronic Venous Insufficiency
BLM CogniZen
Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial
A Randomized, Double-Blind, Placebo-Controlled, Comparator Trial Evaluating Magtein® Magnesium Supplement on Quality of Life as Related to Levels of Stress, Anxiety, Fear and Other Indicators
A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study
Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students
Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course
DERMATOLOGY
BLM Bloom
Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin
Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
Efficacy and safety of a proprietary Punica granatum extract in skin health – a randomized, placebo-controlled clinical study in healthy volunteers
Inhibitory Effect of an Ellagic Acid-Rich Pomegranate Extract on Tyrosinase Activity and Ultraviolet-Induced Pigmentation
Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study
The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products
BLM HairRenew
Efficacy of a wheat polar lipid complex in reducing hair loss and improving hair growth in healthy women: A randomized, double-blind, placebo-controlled clinical study
Recovery Effects of Oral Supplementation with Polar Lipid-Rich Wheat Extracts on Acute Telogen Effluvium: A Randomized Double-Blind Placebo-Controlled Study
The Role of Vitamins and Minerals in Hair Loss: A Review
Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers
The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata patients who had a low serum zinc level
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